Novel single-particle digital assay using plasmonic nanobubbles

The ability to rapidly detect diseases with high precision is of paramount importance, as evidenced by the current COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Researchers have developed a novel strategy for simplified single-particle digital assay based on DIgitAl plasMONic nanobubble Detection (DIAMOND) to meet this urgent and unmet requirement. This new technology provides rapid and ultrasensitive detection of viruses in a one-step homogeneous assay.